NIH R01 · 2025
ROLE OF RNA SEQUESTRATION IN ACUTE MYELOID LEUKEMIA
PROJECT SUMMARY Post-transcriptional mechanisms play crucial roles in maintenance of progenitor cell identity and have been implicated in cancer development, including leukemia. However, our understanding of the role of post- transcriptional regulatory processes in leukemogenesis remains limited. To address this gap, we conducted parallel CRISPR dropout screens in both normal and transformed hematopoietic progenitor cells, identifying the RNA helicase DDX6 as a selective vulnerability of leukemia cells. Our findings reveal that DDX6 is overexpressed in leukemia patients and plays a crucial role in initiating and sustaining acute myeloid leukemia (AML). Importantly, depletion of DDX6 in vivo…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.