NIH R01 · 2024
Molecular Mechanisms of Platelet Alpha Granule Biogenesis
PROJECT SUMMARY Platelets play central roles in hemostasis and thrombosis. Platelet activation triggers secretion and release of contents from α-granules, δ-granules and lysosomes that in turn leads to the recruitment and aggregation of additional platelets and a myriad of physiological responses. While impaired platelet function is associated with disorders that manifest with moderate to severe bleeding, excessive platelet aggregation is a major cause of morbidity and mortality due to its effect in cardiovascular disease and stroke. Alpha-granules are crucial to these platelet functions both in health and disease. However, in spite of the relevance of platelet α-granules for human health,…
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