NIH R01 · 2025
NADPH Oxidase 2 in Parkinson's Disease Pathogenesis
ABSTRACT Reductive-oxidative (redox) imbalance in nigrostriatal neurons has been indicated as an important cause of nigrostriatal degeneration in familial and idiopathic Parkinson disease (PD). While it is generally assumed that the oxidative damage seen in PD derives from dysfunctional mitochondrial electron transport chain, there is growing consensus that NADPH oxidase isoform 2 (NOX2) may be important and, in some cellular systems, the two appear intimately related in a redox regulatory pathway recently termed “ROS-induced ROS production” (RIRP). However, the relevance of NOX2 in PD pathogenesis remains underexplored. Additionally, the in-situ detection of NOX2 activity state has been…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.