Di Ianni Lab

Research focus

NIH R01 · 2025

Dissecting the circuit-level mechanisms of ultrasound neuromodulation

ABSTRACT Transcranial low-intensity focused ultrasound (LIFU) is an emerging modality for noninvasive and targeted modulation of cortical and deep targets in the human brain. LIFU has enormous potential to realize a transformative treatment for myriad neurological and psychiatric disorders, but significant challenges exist for the clinical translation of LIFU neuromodulation protocols due to the unknown underlying neurophysiological mechanisms and the relatively large parameter space that remains poorly understood. Dissecting the mechanistic underpinnings of LIFU neuromodulation with systematic and carefully controlled experimental approaches is a critical step to facilitate the effective…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.