NIH R01 · 2024
Control of precisely timed gene expression during notochord development by Brachyury
PROJECT SUMMARY/ABSTRACT Precise temporal regulation of stage-specific gene expression is fundamental for the proper development of all organisms. Different molecular mechanisms that ensure the regionalized activation of gene expression, such as activator gradients or localized transcriptional repressors, have been elucidated in remarkable detail; however, the structural features of cis-regulatory sequences that enable transcription factors to achieve the timely deployment of their downstream genes remain mostly unclear. The evolutionarily conserved transcription factor Brachyury provides an example of a regulator that controls the spatial and temporal expression of a large number of genes,…
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