NIH R01 · 2025
Epigenetic regulation of genomic stability in beta-cell homeostasis
PROJECT SUMMARY/ABSTRACT Both type 1 and type 2 diabetes result from insulin deficiency, in large part due to the loss of functional beta- cells. Despite significant advances in understanding beta-cell defects in diabetes, preserving and replenishing beta-cells for therapy remains a challenge. A major obstacle is our limited understanding of how beta-cells dynamically modulate their response to changing environment while protecting themselves from damage. Such modulation is essential to respond to developmental cues during beta-cell growth and maturation, and for adapting insulin secretion and maintaining beta-cell resilience in the face of varying metabolic needs and stressors.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.