Dharmakumar Lab

Research focus

NIH R01 · 2025

Developing a Cardiac MRI Guided Therapy for Hemorrhagic Myocardial Infarction

PROJECT SUMMARY Re-establishment of blood flow (reperfusion) in coronary arteries has reduced immediate death from acute myocardial infarction (MI). However, the long-term complications in the chronic phase of MI, especially chronic heart failure (CHF) culminating in major adverse cardiovascular events (MACE), have become epidemic. Currently, ~2 million MI patients in the US are living with CHF; their 5-year survival rate is ~50%. A long-established predictor of CHF is MI size, which is tied to time-to-reperfusion. Reperfusion therapy is lifesaving. Yet, advances in cardiac MRI (CMR) have shown that microvascular obstruction (MVO), - a form of reperfusion injury – is an independent…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.