NIH R01 · 2024
Endocannabinoid Signaling during Early Pregnancy
Regulated trophoblast migration is indispensable for normal placentation. Shallow trophoblast invasion results in pregnancy complications, including preeclampsia, intrauterine growth restriction, and preterm delivery. Invasive trophoblasts, called spiral artery-trophoblast giant cells (SpA-TGCs), maintain connectivity and exhibit an epithelial to endothelial-like transformation when replacing maternal endothelial cells. The mechanism that directs collective and directional cell movement in SpA-TGCs remains unknown. The proposed project aims to study how planar cell polarity (PCP) signaling in cooperation with cannabinoid signaling regulates organized trophoblast migration for placentation.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.