NIH R01 · 2024
A marker-free technology for mapping the epigenome of cell types in mammalian tissues
PROJECT SUMMARY The genome within cells of a multicellular organism is identical, yet distinct cell types display varied functions due to differences in their epigenome. Therefore, mapping the genome-wide epigenetic landscape of different cell types within a tissue is critical for understanding cell type-specific gene expression regulation. Techniques to map epigenetic factors currently rely on our ability to isolate the desired cell types at high purity with certain biochemical assays, such as quantifying protein-DNA contacts, also requiring a large number of starting cells. However, cell type-specific markers and antibodies are frequently unknown or unavailable, presenting a major…
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