NIH R01 · 2024
Mechanisms of amplification and nonlinearity in the mouse cochlea
PROJECT SUMMARY/ABSTRACT Mammalian hearing sensitivity depends on the amplification of sound-evoked cochlear vibrations by outer hair cells (OHCs). How these cells provide amplification across the frequency range of mammalian hearing remains unresolved. This limits our ability to rehabilitate and eventually restore what is missing in ears with OHC damage, which is a common cause of hearing loss. While amplification has been proposed to result from the OHCs’ ability to change length and generate force, multiple sources of low-pass filtering are thought to attenuate this motile response at high frequencies. It is therefore uncertain if OHC motility can work fast enough to provide…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.