NIH R01 · 2025
Effect of Neural Constraints on Movement in Stroke
Project Summary Post-stroke impairments, including muscle weakness, hyperactive muscle (hypertonia) and associated stretch reflexes (spasticity), and loss of independent joint control (flexion synergy), pose significant challenges to routine daily activities, making stroke a leading contributor to motor dysfunction in the United States. Our extensive research has identified abnormally increased motor neuron excitability post-stroke, hinting at elevated spinal norepinephrine (NE) levels. NE, a potent neuromodulator, not only intensifies and prolongs inputs to motoneurons but also increases reliance on indirect contralesional cortico-reticular tracts, as shown in the previous cycle of this…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.