NIH R01 · 2025
Identification and biological effects of microbiome-derived sulfated metabolites
Project Summary/Abstract Recent studies have shown that metabolites produced by human gut bacteria causally influence health and disease. At the same time, the development of modern metabolomic techniques has enabled the investigation of underexplored classes of metabolites. Here, we focus on one such class of underappreciated microbiome- dependent molecules, the sulfated metabolome. While sulfated metabolites were long considered waste products, new studies have revealed that they can have a variety of important physiological roles, including effects on immune response, host metabolism, and neurological function. In addition, recent studies have revealed that these compounds are not only…
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