NIH R01 · 2025
Advancing SUDEP Risk Prediction Using a Multicenter Case-Control Approach
Project Summary Patients with epilepsy have a 25-fold elevated risk of sudden death. Sudden Unexpected Death in Epilepsy (SUDEP) is the most common disease-related cause of premature mortality in people with seizure disorders, affecting 1 of every 1000 patients annually. Despite this, mechanisms and risk factors of SUDEP remain largely unknown. Having ongoing generalized tonic-clonic seizures (GTCS) and no nocturnal supervision are the only definite risk factors, and reducing seizures is the only currently available preventive strategy. Several other clinical factors and potential biomarkers such as prolonged post-ictal generalized EEG suppression (PGES) that follows GTCS, abnormal…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.