NIH R01 · 2024
Impact of seizure onset pattern on temporal lobe seizure propagation through the basal ganglia
SUMMARY The objective of this proposal is to investigate how temporal lobe (TL) seizures with different onset patterns propagate through the basal ganglia (BG) and to evaluate the implication of this circuit in the control of TL seizures. TL epilepsy is the most common form of focal epilepsy and a third of the patients do not respond to drug therapy. Resective surgery and deep brain stimulation can be effective, however, only some patients are eligible and very few become seizure free. There is then a clear need for better and more individualized epilepsy treatments based on a rigorous understanding of the networks and brain structures implicated in TL seizures. Studies on TL seizures have…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.