NIH R01 · 2024
Targeted nutritional approach to restore muscle health and physical activity after sepsis
ABSTRACT Sepsis is a potentially life-threatening complication of an infection in critically ill patients and is characterized by severe tissue breakdown, leading to long-term muscle weakness, fatigue, and reduced physical activity. Early and targeted nutritional intervention is critical in enhancing rehabilitation from critical illness. The continuing high morbidity and mortality rate in sepsis illustrates the clinical and scientific need to dissect the underlying mechanisms by which sepsis induces accelerated catabolic response in muscle, and to assess the effectiveness of targeted nutritional approaches during rehabilitation from sepsis. The rationale is that the mechanistic insights…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.