NIH R01 · 2024
Infection-Dependent Vulnerabilities of Gram-negative Bacterial Pathogens
SUMMARY The larger goal of the project is to identify infection-dependent weaknesses of Gram-negative bacterial pathogens that could be exploited chemically. We focus on the human pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium) and its survival within mammalian cells and use cell culture infection models and small molecules as tools. We and others have observed that some small molecules that are not effective against Gram-negative bacteria in media prevent pathogen survival during infection of cells and animals. Gram-negative bacteria likely become vulnerable during infection to small molecules because a variety of host innate immune mechanisms permeabilize the bacterial…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.