Detre Lab

University of Pennsylvania

NEUROLOGY

Philadelphia · United States

NIH-funded
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NIH R01 · 2024

Academic Industrial Partnership on Advanced Perfusion MRI

PROJECT SUMMARY Arterial spin labeled (ASL) perfusion MRI provides noninvasive quantification of tissue blood flow in physiological units of ml/100g/min using magnetic labeling of blood water as an endogenous diffusible flow tracer and is one of the few MRI parameters whose biological basis is known. ASL MRI has primarily been used in the brain to measure cerebral blood flow (CBF), a key physiological parameter that serves a biomarker of cerebrovascular integrity and regional brain function with a broad range of applications in basic and clinical neuroscience research and in clinical care. ASL MRI was originally conceived by our laboratory at the University of Pennsylvania, and we have been…

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