NIH R01 · 2025
SUMMARY/ABSTRACT A Randomized, Double-Blind, Placebo-Controlled Study of LHP588 in Subjects with P. gingivalis-Positive Alzheimer's Disease Given the increasing incidence of AD worldwide, there is an urgent unmet need for precision medicine approaches that could prevent or delay cognitive decline experienced by Alzheimer’s disease (AD) patients. Mounting evidence suggests that life exposure to brain-penetrant pathogens could contribute to the etiology of AD. One microbial agent recently associated with AD is Porphyromonas gingivalis (Pg). Pg is best known for its role in chronic periodontitis , but epidemiologic and other studies also strongly imply its contribution to cognitive decline.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.