Desrochers Lab

Brown University

NEUROSCIENCES

Providence · United States

NIH-funded
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NIH R01 · 2025

Testing neural mechanisms of sequence monitoring in the frontal cortex across species: integrated fMRI and electrophysiology

PROJECT SUMMARY The ultimate goal of this research program is to determine the neural mechanisms of sequence monitoring across species. This knowledge can contribute to understanding new treatments for disorders where sequential behaviors are disrupted, such as obsessive-compulsive disorder (OCD). Daily, we monitor sequences of visual information such as the series of bus or train stops when looking for the correct exit. Sequence monitoring is the active process of tracking the order of subsequent “states” or steps. Monitoring is distinct from other well-studied sequence processes, such as explicit memorization, or potentially more automatic behaviors such as a series of motor outputs…

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