NIH R01 · 2024
Mechanisms of neural patterning and the generation of neural diversity in the brain
Mechanisms of neural patterning and the generation of neural diversity in the brain. We have shown that neural diversity in the optic lobe of Drosophila is generated by three mechanisms: Each neural stem cell (neuroblast; NB) expresses sequentially a series of temporal transcription factors (tTF) and divides to produce an intermediate precursor that divides once more to generate a NotchON and a NotchOFF neuron. The neuroepithelium that generates NBs is patterned by spatial TFs (sTFs) and by signaling molecules. Different regions of the neuroepithelium generate NBs that undergo the same tTF series but produce different neurons due to spatial patterning of the neuroepithelium of origin. We…
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