NIH R01 · 2024
Diacylglycerol kinase in airway smooth muscle functions
Project Summary Gq family G protein-coupled receptors (GPCR) and receptor tyrosine kinases (RTKs) on airway smooth muscle (ASM) and T cell receptors (TCR) on T cells are critical in orchestrating cellular responses leading to airway hyperresponsiveness (AHR), remodeling and inflammation in asthma. Activation of these receptors leads to the generation of diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3) by the action of phospholipase C. DAG, working in synergy with IP3-Ca2+ signaling and directly activating PKC and Ras guanyl nucleotide-releasing protein, promote ASM contraction and proliferation. However, the independent role of DAG in ASM functions remains less explored. DAG is…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.