Deshpande Lab

Research focus

NIH R01 · 2025

Molecular Pathogenesis of AF10-Rearranged Leukemias

PROJECT SUMMARY There has been considerable progress in the last few years in the characterization of molecular alterations in childhood cancer. Many defining genomic abnormalities as well as transcriptional and signaling networks involved in specific sub-types of pediatric cancers have been identified. However, despite these impressive advances, safe and effective therapies for most pediatric cancers are lacking. Leukemias are the leading cause of cancer-linked mortality in children and for many pediatric leukemias, therapies that can selectively eliminate cancer cells with few undesirable side effects have been elusive. Therefore, there is an urgent clinically unmet need to develop…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.