NIH R01 · 2025
Spatial Restriction of Apoptotic Machinery during Neuronal Apoptosis and Pruning
Project Summary/Abstract Neurons are capable of activating pathways that induce either the degeneration of the entire cell by apoptosis or to selectively degenerate only the axons by pruning. While the main components of the caspase activating machinery during apoptosis and pruning have been identified, a fundamental question of whether the apoptotic machinery is activated throughout the neuronal soma and axons, or is spatially restricted, during these events remains unknown. This question is most relevant in the context of pruning where one predicts the apoptotic machinery to be localized to the targeted axons undergoing degeneration. However, we were surprised to find an unexpected…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.