NIH R01 · 2024
Tissue niches for ILC3 development in newborn's lung
PROJECT SUMMARY : Bacterial pneumonia kills more than one million infants around the world each year. Type 3 innate lymphoid cells (ILC3) are critical for lung mucosal defense against bacterial pneumonia in the newborns. However, the signals that guide pulmonary ILC3s development are incompletely understood. A wave of ILC3s accumulate into the newborn lungs during the first week of life contemporaneous with postnatal lung growth and colonization by commensal microbiota. Clinical interventions in premature infants, for instance, the use of antibiotics alter microbiota and are associated with decreased lung ILC3s and increased risk of pneumonia. Similarly, therapies such as mechanical…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.