NIH R01 · 2024
Basal Forebrain connections to the heart and mind in healthy aging
PROJECT SUMMARY We are facing a growing crisis of a greater number of seniors living with a decline in cognitive function as a common consequence of aging. Once an impairment has reached a level of clinical significance, treatment options are limited. We propose to examine age-related differences in trait and state autonomic control of heart rate and their relation to cognitive performance humans and rats. While cognitive changes may be masked by compensatory efforts, autonomic measures may be more revealing of the underlying age-related changes in the neural substrates and neurochemistry of aging and its clinical course. We will examine these autonomic regulation of heart rate, its…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.