NIH R01 · 2025
Chemical Biology Strategies to Resolve Plasmodium Heat Shock Protein Function
Project Summary Despite modern efforts to eradicate malaria, the disease continues to threaten the lives of over half the world's population. The urgency to uncover novel drug targets in the blood and liver stages of Plasmodium parasites, the causative agents of malaria, is exacerbated by strains resistant to frontline antimalarials. To address this need, a better understanding of pathogen biology is imperative, particularly relating to essential, druggable proteins. The Plasmodium falciparum heat shock proteins 90 and 70-1 (PfHsp90 and PfHsp70-1) are molecular chaperones critical to multiple stages of the parasite's lifecycle. These proteins have N-terminal nucleotide binding domains (NBD)…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.