NIH R01 · 2024
Extrinsic Mechanisms Governing Injury-Induced Axon Degeneration
Summary: Axon degeneration occurs during development of the nervous system as well as neuropathologies including Alzheimer's, Luo Gehrig's, and Huntington's disease as well as stroke, and spinal cord injury. A common but poorly defined feature of all forms of neural degeneration is the emergence of swellings or spheroids that appear prior to irreversible breakdown of the axon. These degenerative spheroids were first observed in the early 1900's by Cajal but their function has gone undescribed until our recent work. We found that in both developmental and pathological contexts, diverse degenerative triggers converge on spheroid formation. In both contexts, spheroids grow to the point of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.