Depner Lab

Research focus

NIH R01 · 2025

Mechanistic Contribution of Internal Circadian Misalignment to the Cardiometabolic Risk of Sleep Loss

PROJECT SUMMARY/ABSTRACT Over one in three Americans regularly sleep less than the recommended 7 hours per night and thus obtain insufficient sleep. Compared to adults who maintain adequate sleep durations, adults who maintain insufficient sleep are at higher risk of developing obesity and type 2 diabetes (T2D). Furthermore, experimentally imposed sleep restriction in otherwise healthy adults can impair insulin sensitivity to levels commonly observed in people with pre-diabetes or in aging. Given the strength of this rigorous body of evidence, clinical guidelines recommend “healthy sleep” to help prevent and manage cardiometabolic disease. However, effective interventions to increase sleep…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.