NIH R01 · 2025
Project Summary/Abstract -- DePas The emergence of nontuberculous mycobacteria (NTM) as dangerous, antibiotic resistant pulmonary pathogens is outpacing research into their mechanisms of pathogenesis. Our long-term goal is to characterize NTM in the infection environment and develop new therapeutic approaches aimed at specific in vivo bacterial activities. The objective of this proposal is to directly assess NTM biofilm formation and growth rate in situ and determine how the infection environment impacts these processes. We hypothesize that the spatial and chemical environment of sputum from people with Cystic Fibrosis (CF) sputum supports the formation of antibiotic tolerant, slow-growing…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.