NIH R01 · 2024
Information Integration and Energy Expenditure in Eukaryotic Gene Regulation
Project Abstract Gene regulation – how genes are turned on in the right place, at the right time and in the right amount – is a problem central to most areas of biology and medicine. Our understanding of gene regulation arose from classical studies in bacteria: proteins called “transcription factors” (TFs) bind to regulatory DNA sequences and recruit RNA polymerase (RNAP). The situation in eukaryotes is far more complicated. For example, eukaryotic DNA is packaged around nucleosomes into chromatin and external sources of energy, such as ATP, are used to reorganise chromatin, remodel nucleosomes and post-translationally modify regulatory proteins. Pioneering studies from several laboratories…
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