NIH R01 · 2025
Redox-sensitive activation of REDD1 in diabetic retinopathy
Project Summary Diabetes promotes cellular concentrations of the stress response protein Regulated in Development and DNA damage 1 (REDD1) in the retina, which contributes to the development of retinal disease and impaired visual function. Indeed, intravitreal administration of a siRNA targeting the REDD1 mRNA has demonstrated some limited therapeutic benefit in improving visual function of patients with diabetic macular edema. However, the approach was abandoned over a decade ago due to its failure to outperform vascular endothelial growth factor (VEGF) blockade, despite the partially effective results of this current standard of care. During the prior funding period, we discovered that…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.