NIH R01 · 2024
Unravelling MyD88-dependent and independent mucosal immunity to Toxoplasma
Project Summary/Abstract The long-term objective of this proposal is to understand inductive and effector mechanisms of host defense in the intestinal mucosa. We use as a tool the intracellular protozoan Toxoplasma gondii, an orally acquired opportunistic pathogen inducing strong protective Th1- and IFN--based immunity and that is a significant health hazard in immunocompromised populations. Signaling through the adaptor molecule MyD88 is necessary for optimal initiation of immunity and resistance to this pathogen. While IL-1 family cytokine receptors use MyD88, the primary role of this signaling adaptor during T. gondii infection is believed to be in Toll-like receptor (TLR) signaling.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.