NIH R01 · 2024
Alcohol-induced changes in gut flora and intestinal metabolites increase portal endotoxin level, which is directly associated with intestinal barrier dysfunction and is one of the well-recognized contributing factors to the pathogenesis of ALD. Gut fucosylation is a key force in maintaining a homeostatic relationship between the gut and its microbiota. Nevertheless, it is unclear how host fucosylation machinery contributes to alcohol-associated barrier function and microbial translocation. It is shown that epithelial α1,2-fucosylation regulates the colonization of E. faecalis, which causes more severe alcoholic hepatitis. Our initial studies found that alcohol consumption reduces the levels…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.