NIH R01 · 2025
Spatially resolved multi-omics profiling of human hippocampus in Aging and Alzheimer's Disease
Project Summary Human hippocampus is among the most complex tissue types with a wide range of cells organized in spatially precisely defined regions. Alzheimer’s disease (AD) is one of the diseases strongly affected the hippocampal region, which underlies the core feature of the disease-memory impairment and remains refractory to therapy, due in part to the complexity of gene regulatory network coupled with cell-type-specific mechanisms of AD progression. What types or subtypes of cells are affected by this process and their spatial heterogeneity in the tissue context as well as how these cells impact the tissue environments remain poorly understood, which precludes the development of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.