NIH R01 · 2025
Development of Stem Cell-based Therapies for Limbal Stem Cell Deficiency
Project Summary Limbal stem cell deficiency (LSCD), a blinding corneal disease, is caused by damage to the limbal stem cells or their niche microenvironment. The clinical presentation of LSCD varies greatly based on the severity of the condition, determined by the quantity of functional limbal stem cells (LSCs) remaining in the eye. Therefore, accurately diagnosing and staging LSCD through clinical examination alone is challenging and subjective. The lack of standardized diagnostic methods and disease severity staging has hindered therapy advancements, as uniform criteria are needed to establish standardized outcome measures for comparing the efficacy of different treatments. Moreover,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.