Deng Lab

University of Pennsylvania

OTHER HEALTH PROFESSIONS

Philadelphia · United States

NIH-funded
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NIH R01 · 2025

Placebo-Controlled Phase II Randomized Clinical Trial of Photobiomodulation Therapy in Head and Neck Cancer Survivors with Chronic Lymphedema

PROJECT SUMMARY There are over half a million head and neck cancer (HNC) survivors in the United States. More than two-thirds experience chronic soft tissue swelling (lymphedema) in the head and neck region. Lymphedema not only has adverse cosmetic and psychosocial consequences but can cause a substantial impact on critical functions (e.g., swallowing) and result in decreased range of motion in the jaw, neck, and shoulders. The standard of care for acute or early-stage lymphedema is complete decongestive therapy (CDT). After completion of CDT, 30%-40% of survivors still have clinically evident residual lymphedema that can progress to chronic lymphedema. Currently, there are no proven…

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