NIH R01 · 2025
Distinct functions of adipocyte-derived FGF21 in obesity
Title: Distinct functions of adipocyte-derived FGF21 in obesity Summary Obesity is rapidly reaching epidemic proportions, with an urgent need for novel strategies for weight loss. Fibroblast growth factor 21 (FGF21) is a hormone derived from the liver and adipose tissue that plays a beneficial role in energy homeostasis when given pharmacologically, but is paradoxically activated by both fasting and feeding signals. Obesity is associated with elevated levels of circulating FGF21 in rodents and humans, which correlates with adiposity and adipose tissue FGF21 mRNA levels, suggesting that obesity- associated FGF21 derives from adipose tissue. While the beneficial effects of pharmacological…
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