NIH R01 · 2024
PROJECT SUMMARY/ABSTRACT Formation of anti-citrullinated protein antibodies (ACPA) is an early step in the development of rheumatoid arthritis (RA). Serum ACPA are highly predictive of developing RA and can directly promote joint damage. Yet, there remains a major gap in our understanding of ACPA development, including where and how they are initially triggered. Importantly, to achieve the NIH's mission of disease/disability prevention in RA, an improved understanding of the initiating factors and pathways that lead to ACPA is needed as these factors/pathways would be novel targets for RA prevention. ACPA originate several years prior to the onset of arthritis in RA, and data support that…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.