NIH R01 · 2025
Role of cholesterol in the pathogenesis of hepatic encephalopathy
Liver cirrhosis results from long-term continuous damage to the liver leading to irreversible buildup of scar tissue impairing liver function. Cirrhosis can occur as a consequence of various chronic liver diseases including alcoholic liver disease and non-alcoholic fatty liver disease. One of the most serious complications of cirrhosis is hepatic encephalopathy (HE), a pathological state characterized by neurological deficits that significantly impair quality of life and overall prognosis. Furthermore, these neurological impairments can be irreversible, persisting after resolution of liver injury. Our current understanding of the events leading to the development of HE is limited, resulting…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.