NIH R01 · 2025
REGULATION OF PROTEOSTASIS AND TAUOPATHY BY MALTOSE-INDUCED SIGNALING
PROJECT SUMMARY Proper signaling is necessary for homeostasis in multicellular organisms. Once considered mere byproducts of cellular metabolism, small metabolites have now emerged as an important class of signaling factors that regulate tissue and whole-body functions. However, the role of small metabolites in proteostasis and age-related neurodegeneration is largely unexplored. We have recently found that the disaccharide maltose and the maltose- producing amylase enzyme Amyrel preserve proteostasis of the central nervous system (CNS) during aging in Drosophila. Specifically, Amyrel and maltose protect from tauopathy and prevent the age-related accumulation of poly-ubiquitinated proteins…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.