NIH R01 · 2024
Networks Tools to Understand Sex- and Gender-Specific Drivers of Disease
ABSTRACT Complex human diseases including chronic obstructive pulmonary disease and many human cancers, exhibit strong differences between males and females in risk, disease progression, and response to therapy. Our previous work in normal and disease tissues from males and females has shown that while there are rarely significant differences in genetic associations or gene expression that can explain the observed sex-based differences, modeling gene regulatory processes can lead to key insights into the likely drivers of sex differences in health and disease. This suggests that both sex-based factors and epigenetic variability likely work together to help define risk and response. This…
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