NIH R01 · 2025
Cancer Cell Intrinsic Interferon-I pathway Activation by Fractionated Radiation
Recent evidence indicates that the presence of conventional dendritic cells type 1 (cDC1) in the tumor microenvironment (TME) is required for response to immune checkpoint blockade (ICB) therapy. In addition to cross- presenting cancer cell-derived antigens to CD8+ and CD4+ T cells, cDC1 promote tumor infiltration by effector T cells, and support their survival and function. Thus, interventions that improve cDC1 recruitment to the TME could enhance patient responses to ICB. Focal radiation therapy (RT) increases responses to ICB therapy, at least in part by inducing type I interferon (IFN-I) and driving cDC1 into the irradiated tumor. We have previously shown that cDC1 are essential for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.