NIH R01 · 2025
More than 80% of adults with depression endorse one or more symptoms of insomnia, such as high sleep latency (difficulty falling asleep). When comorbid insomnia is not addressed, it results in worsened depression severity, a doubled probability of relapse and increased risk of suicide. Conversely, cognitive behavioral therapy for insomnia (CBT-I), a treatment solely aimed improving sleep, reduces depression with rates similar to conventional antidepressants. Although this efficacy reflects the interrelationship between sleep and depression, CBT-I’s antidepressant mechanism of action is currently unknown. One potential mechanistic pathway is through the metabotropic glutamate receptor…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.