NIH R01 · 2025
Characterize the Landscape and Origin of Hybrid Peptides in Beta Cells
Project Summary/Abstract In Type 1 Diabetes (T1D) autoreactive CD4 T cells mediate the destruction of insulin producing beta-cells. The reasons for this misguided attack are poorly understood. Post-translational protein modifications could provide plausible explanations for the existence of autoreactive T cells in T1D. Hybrid insulin peptides (HIPs) are a form of post translationally modified antigens that form in beta-cells through the covalent ligation between proinsulin fragments and other beta-cell peptides. The resulting HIPs contain non-genomic amino acid sequences making them plausible targets for pathogenic T cells in T1D. Various HIP-reactive CD4 T cell clones were shown to trigger…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.