NIH R01 · 2025
“Two-hit” model for lymphatic malformations.
PROJECT SUMMARY Complex lymphatic anomalies (CLAs) are rare diseases with variable clinical manifestations caused by the abnormal development of lymphatic vessels. CLAs include central conducting lymphatic anomaly (CCLA), generalized lymphatic anomaly (GLA), Gorham-Stout disease (GSD), and kaposiform lymphangiomatosis (KLA). CLA patients exhibit a variety of phenotypes, such as tortuous dilated lymphatic vessels, multifocal lymphatic malformations (LMs), and ectopic lymphatic vessels in bone. Unfortunately, existing treatments for CLAs have significant side effects and are not effective in all patients. Therefore, there is an urgent need to identify new, safer treatments for CLAs. We and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.