NIH R01 · 2024
PROJECT SUMMARY Ion channels control such diverse processes as fertilization, proliferation, development, learning and memory. Ion channels are multispan transmembrane proteins that transport ~106 to 107 ions per second across membranes. Precise spatial and temporal regulation of ionic flux is the fundamental principle by which ion channels control such a diverse array of signaling modalities. Spatial regulation is achieved by targeting channels to subcellular compartments ensheathed in membranes such as the endoplasmic reticulum (ER) or endosomes, whereas temporal regulation by specific signals controlling opening and closing of channels. The primary cilium is an antenna-shaped protrusion…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.