Delling Lab

Research focus

NIH R01 · 2024

Prospective sudden cardiac death risk stratification using CMR and echocardiography machine learning in mitral valve prolapse

PROJECT SUMMARY Mitral valve prolapse (MVP) is a common valvulopathy affecting over 170 million worldwide. Every year, 0.4- 1.9% of individuals with MVP will develop sudden cardiac arrest (SCA) or sudden cardiac death (SCD), and 7% of SCDs in the young are caused by MVP. However, predictors of this devastating outcome are not readily available, and indications for a primary prevention implantable cardioverter defibrillator (ICD) in MVP are lacking. Severe mitral regurgitation explains only 50% of SCA cases in MVP. SCD/SCA risk has also been linked to a bileaflet phenotype with mild MR, mitral annular disjunction (MAD), and left ventricular focal fibrosis on cardiac magnetic resonance…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.