NIH R01 · 2025
Postsynaptic kinase/phosphatase networks in amyloid beta-induced synaptic dysfunction
Project Summary/Abstract Postsynaptic kinase/phosphatase networks in amyloid b-induced synaptic dysfunction Impaired synaptic function and synapse loss are early hallmarks of Alzheimer’s Disease (AD). There is strong evidence that amyloid beta (Ab) leads to AD-related synapse dysfunction and cognitive impairment. For example, long-term potentiation (LTP), a key form of plasticity for learning and memory, is disrupted in mouse models harboring familial AD-linked mutations that lead to Ab accumulation. Even acute applications of soluble Ab oligomers block LTP within minutes and lead to synapse loss within days. It is increasingly appreciated that Ab hijacks normal synaptic signaling pathways…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.