NIH R01 · 2025
Circadian Regulation of Cardiac Electrophysiology
Abstract. Circadian clocks play a fundamental role in aligning physiological and behavioral processes to predictable changes in the daily environment. For decades, circadian signaling has been implicated in the development of cardiac arrhythmias and sudden cardiac death (SCD) in individuals with cardiovascular disease. However, numerous critical knowledge gaps persist regarding the connection between circadian clocks, circadian rhythms, and SCD. This research proposal addresses these knowledge gaps by investigating the molecular mechanisms underlying the circadian regulation of ion channel transcripts and proteins that impact arrhythmia susceptibility. Aim 1 will elucidate the molecular…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.