Delgoffe Lab

Research focus

NIH R01 · 2024

Dissecting the role of hypoxia in T cell differentiation in cancer

PROJECT SUMMARY/ABSTRACT Immunotherapeutic treatments for cancer, especially the use of monoclonal antibody mediated blockade of `checkpoint' molecules like PD-1, has changed the treatment paradigm for patients with solid tumors like melanoma. However, only a subset of patients benefit from these therapies, due to several resistance mechanisms concentrated within the tumor microenvironment (TME), the site of action of cytotoxic T cells. T cells must contend with physical barriers to infiltration, immunosuppressive cell types, the expression of co- inhibitory ligands on target cells, and a harsh metabolic environment produced by cancer cells. In addition to T cell-extrinsic…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.